Description:
The ability to manipulate tumor cells ex-vivo is in many ways essential to their utility as cancer models. Gastrointestinal cancer cells have the property of being able to form 3-dimensional spheroids in culture called organoids. Organoids preserve the molecular, structural and functional characteristics of their tissues of origin, thus providing an attractive opportunity to study cancer biology. This cell model permits in-vitro manipulation before engraftment into a mouse for in-vivo studies.